He was in a state of permanent depression.

他一直处于消沉状态。

《牛津词典》

Studies have also found that consistently elevated levels of stress hormones, like cortisol, can lead to permanent damage in certain brain regions linked to depression.

研究还发现，不断提高的应激激素水平，如皮质醇，将导致大脑与抑郁症相关的部分区域的永久性损伤。

youdao

Others will be mired in permanent depression.

FORBES: The Incredibly Uneven Recovery

Rather than a higher return going forward, this price decline could reflect a consensus opinion that a massive depression is coming -- a 34% permanent decline in earnings and dividends and a massive wave of bankruptcies.

WSJ: Is Now the Time to Buy Stocks?