We compared the effect of electroporation in vitro and in vivo percutaneous penetration and found that the optimal electrical parameters of the two conditions are basically the same. So we can explore the laws of transdermal through in vitro experiments.
对电致孔作用下体外与体内经皮渗透试验进行比较,发现二者最优电学参数条件基本一致,可以利用体外试验研究药物的透皮规律;同时发现药物透过量差异较大,因此为保证临床用药的安全有效,经皮给药系统的开发过程需要进行体内研究。
参考来源 - 秦艽多成分在电致孔作用下的透皮研究·2,447,543篇论文数据，部分数据来源于NoteExpress
OBJECTIVE: To study diclofenac sodium percutaneous penetration in its aerosol.
目的：考察双氯芬酸钠气雾剂中双氯芬酸钠的透皮吸收情况。
Aim To reconstruct of a tissue engineering skin in vitro for the study of the use of drug percutaneous penetration and metabolism.
目的利用离体皮肤渗透技术研究了熊果苷柔性脂质体的经皮渗透和几种渗透促进剂对其影响。
Objective to study the effect of electric field direction on the percutaneous penetration of the non-ionic drug caffeine mediated by skin electroporation and iontophoresis.
目的研究电穿孔及离子导入时电场方向对分子型药物咖啡因经皮渗透的影响。
应用推荐