With Pepys and Lowndes he became one of the greatest and most efficient of our civil servants.

与佩皮斯和朗兹一起，他成为我们最伟大最有成效的公务员之一。

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Now, for the first time, a wider social group, including both aristocrats and commoners such as Pepys with fashionable aspirations, set the tone.

现在，第一次，一个更广泛的社会群体，包括贵族和佩皮斯这类追逐时尚的平民，有了发言权。

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On April 10th 1663, Samuel Pepys, diarist and man-about-London, noted that he had enjoyed “a sort of French wine called Ho Bryan that hath a good and most particular taste that I never met with”.

1663年4月10日，赛缪尔•佩皮斯（Samuel Pepys），日记作家和伦敦社交场上的花花公子，记录道他品尝了“一种叫做奥布莱恩（Ho Bryan）的法国葡萄酒，有着我从未体验过的美妙绝伦的口味”。

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"As far as Alzheimer's is concerned, all this is something new to try out, " says Pepys.

FORBES: A New Drug To Treat Alzheimer's?

Pepys' drug, described in tomorrow's issue of Nature, is part of a growing trend in brain research.

FORBES: A New Drug To Treat Alzheimer's?

Right now, Pepys' lab is funding the trials on its own, although Roche could get involved down the line.

FORBES: A New Drug To Treat Alzheimer's?