The club said Mr Pembridge was known to his friends as "Curly" and there had been a "humbling" outpouring of messages of support for him on social networking sites.
Gary Speed, Robbie Savage, Mark Delaney, John Hartson, Mark Pembridge, Andy Melville, Ryan Giggs and Jason Koumas have all quit Wales since Hughes left to take over at Blackburn in 2004.
Gary Speed, Robbie Savage, Mark Delaney, John Hartson, Mark Pembridge, Andy Melville and Ryan Giggs have all called time on their international careers since Hughes left to take over at Blackburn in 2004.