...和TGF-α五个基因表达的诱导程度；采用免疫荧光分析方法,检测磷酸化表皮生长因子受体(p-EGFR)和磷酸化丝裂原激活蛋白激酶(p-MAPK)蛋白表达；采用mRNA荧光原位杂交法与激光扫描共聚焦显微镜结合及免疫组织化学方法,测定角蛋白17(CK17)和角质形成细胞转谷氨酰酶(...
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...磷酸化EGFR(phosphorylated EGFR,p-EGFR)和磷酸化丝裂原激活蛋白激酶(phosphorylated mitogen-activated protein kinase,p-MAPK)]在蛋白水平表达的影响。
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p mapk gene p38mapk基因
p mapk system p38mapk通路
p mapk kinase p42激酶
p mapk signal pathway p38mapk信号通路
p mapk signal transduction p38mapk信号通路
phospho p 38 mapk 磷酸化pmapk
phospho-p 38 mapk 磷酸化pmapk
p 38 mapk pathway pmapk信号通路
p 38 mapk inhibitor pmapk抑制剂
Results The cell viability, protein content, colony formation and DNA synthesis were significantly inhibited by MAPK ASO, the inhibitory rate was 52.6% , 50.5% , 54.9% and 47.5% respectively(P< 0.01).
结果：MAPK反义寡核苷酸可明显抑制细胞活力、蛋白质含量、集落形成和DNA合成，其抑制率分别为52。6%、50。5%、54。9%和47。5%，与对照组比较差异有显著性（P<0。01）。
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