It is important to determine whether a given dosage of CC results in ovulation. Most doctors rely on the menstrual pattern, ovulation prediction kits, measurement of serum progesterone levels or the BBT chart to monitor a patient's response to the standard dose of clomiphene. A BBT chart is a chart in which the patient's body temperature upon awakening is plotted every morning before she gets up. The readings help identify ovulation, which is indicated by a persistent temperature rise of one-half degree or more. If there is doubt, however, measuring the progesterone level about 14 to 18 days after the start of clomiphene, or examining the ovaries with ultrasound, can help to determine if and when ovulation occurred. If ovulation does not occur at the 50-mg dosage, CC may be increased by 50-mg increments in subsequent cycles until ovulation is achieved. Although dosages in excess of 100-mg are not approved by the Food and Drug Administration, your physician will determine the appropriate dose for you. Occasionally, the physician may choose to add other medications to clomiphene if the drug is not successful in inducing ovulation. For more information about BBT charts and ovulation detection, refer to the ASRM Patient Fact Sheet titled, Ovulation Detection.
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