They secured a victory in the face of overwhelming odds.

尽管情况非常不利，他们仍得到了胜利。

《牛津词典》

Vivien Thomas, who had no formal medical training, in struggling against overwhelming odds, he became a cardiac surgeon and eventually to receive an honorary doctorate from Johns Hopkins University.

薇薇安·托马斯没有接受过正式的医学训练，但他努力抗击重重困难，成为了一名心脏外科医生，并最终获得了约翰·霍普金斯大学的荣誉博士学位。

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We can't hope to prevail against such overwhelming odds.

我们不能希望战胜这种势不可挡的力量。

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The picture they paint is of stoic defiance in the face of overwhelming odds.

NEWYORKER: Booted

Against overwhelming odds and precious little help from Poland's allies, the underground fought on for 63 days before finally capitulating.

BBC: Irena Sendlerowa is modest about her selfless actions

In most cases passion is an asset capable of carrying you through tough times, sharpening your perspective, revealing purpose, and helping you succeed in the face of overwhelming odds.

FORBES: Passion: Leadership Asset or Liability?