Objective To discuss the mechanism of age-related the osteoblast and osteoclast differentiation from marrow cells and discuss the mechanism of aged bone loosing disease.

目的从骨髓细胞分化角度研究年龄相关的成骨和破骨细胞分化的机理，探讨老年性骨质疏松症的发生机理。

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Results RAW264. 7 cells show TRAP-negative with monocyte or 2 nucleus, expressing osteoclast phenotypic and functional genes without capability of absorbing bone tissue.

结果raw264.7细胞TRAP染色阴性，单核或2个核，能表达破骨细胞表型和功能基因，无骨吸收功能。

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Postmenopausal osteoporosis is a kind of metabolic osteopathy, whose cause is that bone absorption of osteoclast is more forceful than osteogenesis of osteoblast.

绝经后骨质疏松症是一种代谢性骨疾病，是绝经后妇女雌激素水平降低导致破骨细胞的骨吸收大于成骨细胞的骨形成作用。

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