Oral clefts happen early in pregnancy, before many women even know they are pregnant.

唇腭裂发生在怀孕女性的第一孕期，而这时候很多女性可能还不知道自己已经怀孕。

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Alternative medications that have a lower risk of oral clefts and other adverse birth outcomes should be considered.

如果有，应当给这些病人使用唇腭裂和其他不良分娩结局发生风险更低的其他替代药物。

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Alternative medications that have a lower risk of oral clefts and other adverse birth outcomes should be considered for these patients.

如果有，应当给这些病人使用唇腭裂和其他不良分娩结局发生风险更低的其他替代药物。

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Women with similar medical profiles but no topiramate exposure had a prevalence of 0.07% babies born with oral clefts.

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Because of the high risk of oral clefts in fetuses exposed to topiramate, women should have a negative pregnancy test before starting Qsymia and every month while taking the drug, in addition to using contraception.

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The FDA said exposure to topiramate in pregnancy "is likely to be associated with a two- to fivefold increased prevalence of oral clefts, " a defect of the mouth that can be later treated with surgery.

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