A change, or mutation, happens when the order of the letters changes.

当这些字母的排列顺序有所变化时，就会发生基因突变。

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By detecting its structure in the tumour tissue, we find that the sum of its deletion or mutation rate reaches 35%.

通过检测肿瘤组织中该基因的结构，发现该基因在肿瘤组织中的缺失或突变率的总和达到35%。

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Examples of so-called SNP diseases are sickle-cell anemia and Huntington's disease, where a single variant or mutation has a dramatic effect.

镰状细胞性贫血和亨庭顿综合症就是这样的疾病，单个变异起了很大的作用。

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So the access that a cell has to certain kinds of genes, or chemical modifications of DNA, not chemical modifications that change the base pairs, that would be a mutation.

因此细胞变化的途径应该是对某些基因,或者DNA进行化学修饰,不是更改碱基对,更改碱基对就是突变了

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