Also, they couldn't clap too much or it would substantially increase the length of the speech.

还有，他们不能鼓掌太多，不然发言的时间会大幅度增加。

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Secondly, the new basal analogues, whether it is detemir or glargine, have shown that they do not substantially increase weight because they are basal insulin.

其次，新的基础类似物，无论是地特或甘精胰岛素，均已证实事实上并不增加体重，因为它们是基础胰岛素。

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