Feeling down, depressed, or hopeless.

心情忧郁，绝望，无助，或悲伤。

youdao

Or they may urge you to visit your doctor when you feel overly anxious, sad or hopeless.

当你过度焦虑、忧伤、绝望时，朋友会陪你看医生；

youdao

If one is in a situation that is intolerable or hopeless in its destructiveness then certainly it is foolish to continue.

假如一个人处于一个其毁灭性令人无法忍受或毫无希望的处境，那么当然，继续下去是愚蠢的。

youdao

Such feelings of sadness would only break my heart, or make me feel unhappy and hopeless.

VOA: special.2010.07.11

So I don't want anybody feeling that if he or she is down here that it is hopeless at this point. It is not.

我不想让任何人感到,来到这的他或她,在这点上是无望的，不是这样。

麻省理工公开课 - 固态化学导论课程节选

But no matter how tired or hopeless I am feeling, hip-hop helps me look beyond my own circumstances to find the determination I need to move forward.

NPR: Finding Hope in Hip-Hop

But I can't say I felt desperate or hopeless.

CNN: Syrian refugees in Lebanon facing bitter winter

The inner workings of the brain are so opaque that "we don't even have good theories for what might be going on" when people become hopeless or suicidal, Deisseroth says.

FORBES: Magazine Article