This hypercortisolemia is assumed to result in alterations in the glucocorticoid receptors, which become less functional, or downregulated, or "glucocorticoid resistant," in some depressed patients.
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Their average amplitudes were differentially up - or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs.
它们的平均振幅是依赖精确的后突触ap与EPSP时间，相差性的上下控制。
"You could find that a molecule is up or down-regulated, but whether that relates to a consumer noticing a difference is a big jump," says Diona Damian at the University of Sydney, Australia.
“你可能会发现某种分子被人为控制增长或衰减，但它引起的差异是否能被消费者注意到，这是一个飞跃。”澳洲悉尼大学的戴奥娜。达米安说。
Down-regulated activity and absolute or relative absence of growth factors and their receptors in diabetic foot ulcer is the pathophysiologic basis of wound hard to heal.
溃疡创面局部生长因子及受体活性下降和数量的绝对或相对缺乏是其难以愈合的病理生理基础。
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