Let's attack one problem at a time.

咱们一次全力处理一个问题。

《牛津词典》

It was a great trip except for one problem.

这是一次很棒的旅行，除了一个问题。

youdao

One problem is that many people think windmills are very ugly.

一个问题是许多人认为风车很丑。

youdao

Tell us about a time when you have tried to solve one problem but unexpectedly produced another.

VOA: special.2010.05.25

Let me cluster them because really what I have, sorry, separate them out. I've gone from one problem size eight down to eight problems of size one.

让我把它们聚集起来，因为已经得到我想要的，抱歉，把它们分开来,现在我从一个长度为8的问题,得到了八个长度为1的问题。

麻省理工公开课 - 计算机科学及编程导论课程节选

One problem is that they're not always accurate and there's a couple of factors that could lead them away from accuracy.

其中一个问题就是它们并不总是准确的,有几个因素,能减低它们的准确性。

耶鲁公开课 - 心理学导论课程节选

There's only one problem: you can't seem to pull in a reliable OTA (over-the-air) signal.

ENGADGET: blogger-avatar

One problem: Canandaigua's acquired jug wines--Paul Masson, Inglenook and Almaden--competed for the same customers.

FORBES: Up From the Gutter

One problem, say Chen's critics, was that he didn't forewarn his top advisers of his announcement.

CNN: Did He Say 'One China'?