One major difference between these computers concerns the way in which they store information.

这些计算机之间的一个主要差异涉及其储存信息的方式。

《牛津词典》

One major difference is labor costs.

唯一大的不同就是劳动力成本。

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One major difference is the adjustment process.

一个主要的不同是调整过程。

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Mister Gray says one major difference is the way people react to the hormone testosterone.

VOA: special.2009.03.24

One major difference between electron affinity and ionization energy is that when we talked about ionization energy, remember ionization energy always has to be positive.

电子亲和能,与电离能之间最大的不同就在于,当我们提到电离能的时候，记得电离能总是正的。

麻省理工公开课 - 化学原理课程节选

There is one major difference: Nearly all the stock will be produced in China.

WSJ: The New Cachet of 'Made In China'

And he also cited one major difference compared to past matches at Chelsea under Benitez.

BBC: Reds 'can halt jinx at Chelsea'

One major difference, beyond cost, is that the 100K strands are more difficult to handle and shape.

BBC: Knitting and baking the cars of the future