oncotherapy sensitizer 肿瘤治疗增敏剂
Some HSV-TK/GCV and CD/5-FC clinical treatment projects have been validated by FDA. Due to the different sensitivity of cancer cells to the suicide gene therapy,elevating drug resistance treated with only one system, complementarity in the mechanisms of CD/5-FC and HSV-TK/GCV, the combination of these two systems can not only increase the lethal effect of cancer cells, improving the treatment effect, but also enlarge the oncotherapy spectrum, reducing the drug resistance.
鉴于不同类型肿瘤细胞对自杀基因系统的敏感性不同、单一自杀基因系统治疗时部分肿瘤细胞易产生耐药以及CD/5-FC和HSV-TK/GCV系统的作用机理具有很强的互补性,联合应用此两系统不仅可以提高肿瘤细胞杀伤作用,改善治疗效果,而且可以扩大肿瘤治疗谱,减少耐药现象发生。
参考来源 - 慢病毒介导的双自杀基因靶向治疗大肠癌的实验研究·2,447,543篇论文数据，部分数据来源于NoteExpress
The metastasis of malignant tumors is one of the difficulties in oncotherapy.
恶性肿瘤的远处转移是肿瘤治疗中的难点之一。
The objective of oncotherapy is to prolong the life time of patient, that is to say, patient and disease are coexisting.
肿瘤治疗的目的在于延长患者生存时间，即与疾病共生存。
New mode of minimally invasive therapy combined with biotherapy is expected as an important ingredient of oncotherapy in the 21 century.
微创治疗联合生物基因治疗的新模式将成为新世纪肿瘤治疗的重要组成部分。
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