Proline-directed phosphorylation sites like this one are often targeted by CDKs and MAPKs and can often dramatically affect protein conformation (4,5).

类似这种的脯氨酸导向的磷酸化位点通常是CDKs和MAPKs的靶标，并往往能显著影响蛋白质的构象（4，5）。

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The industry needs new accounting systems but it continues to muddle along with systems that have failed, often dramatically.

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Apparently, Home Depot made the same mistake as some other companies that entered China without understanding the local market, which is often dramatically different from their home market.

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The prices of these drugs in Europe are often dramatically lower than in the U.S., which the report says could be because of the negotiating power of single-payer systems over private insurance.

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