...TM）外，还可能通过诱导某些基因的表 达或功能改变导致DNA复制差错，从而在未损伤部位形成非定标性突变（nontargeted mutation，NTM）。非定标性突变是外源性DNA损伤剂造成基因组遗传不稳定的结果。
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Previous report from this laboratory proved that alkylating agents, N-methyl-N’-nitro-N- nitrosoguanidine (MNNG) could induce genetic instability in vero cells, which has characteristic manifestation of delayed developed mutagenesis happened at undamaged base sites of DNA (nontargeted mutation).
本实验室曾证明烷化剂甲基硝基亚硝基胍（N-methyl-N’-nitro-N-nitrosoguanidine, MNNG）可诱发vero细胞的遗传不稳定状态，表现为延迟发生的非损伤部位DNA突变率的增加（非定标突变）。
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