Nonlinear mixed models.

非线性混合模型。

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Objective To explore the application of nonlinear mixed models in ordered categorical data of cross-over trial analysis and hence provide methodology reference.

目的探讨非线性混合效应模型在交叉试验等级资料中的应用，为临床试验交叉设计资料的正确分析提供方法学参考。

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Finally, the precision of mixed models was compared with the precision of conventional nonlinear ordinary regression analysis method based on validation data.

最后，利用验证数据对混合模型方法与传统的非线性回归模拟方法进行精度比较。

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