CONCLUSION The dissolution rate of NFDP can be improved greatly by solid dispersions with proper ratio of drug and carrier.
结论药物与载体合适比例的固体分散物明显提高其体外溶出速率。
OBJECTIVE The solid dispersion method was adopted to enhance the dissolution rate of nifedipine (NFDP) which is a poorly water-soluble drug.
目的 采用制剂技术提高难溶性药物硝苯地平体外溶出速率。
RESULTS the dissolution rate of NFDP-PVP solid dispersions was much faster than that of the physical mixtures, and tended to increase with the increase of the proportion of the carrier.
结果固体分散物体外溶出速率明显高于机械混合物及硝苯地平原料药的体外溶出速率，且随载体比例增加而增大。
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