Thus, our study defines a new step in the control of NFAT activation that involves an immunoregulatory function of LRRK2 and has important implications for inflammatory bowel disease.

因此，我们的研究定义了调控NFAT激活作用之新的一个步骤，其涉及到LRRK2的免疫调节功能并对炎症性肠道疾病具有重要的影响。

youdao

The results showed that the DNA binding activity of NFAT gradually decreased , with trough value of NFAT binding activity , accounting for 41% of the control, observed at 4d after injury.

结果显示，创伤后脾细胞NFAT的DNA结合活性逐渐下降，至伤后4天时下降最明显，仅为正常对照组的41%。

youdao

Drugs that inhibit calcineurin or NFAT may also treat diseases in which the beta cells produce too much insulin, such as hypoglycaemia or some pancreatic tumours.

BBC: NEWS | Health | Hope for new diabetes treatment

The researchers said drugs that enhance the activity of calcineurin or NFAT could become a new treatment for type-2 diabetes, in which the beta cells do not produce enough insulin.

BBC: NEWS | Health | Hope for new diabetes treatment