2007年第四季度的净盈余包括4.41亿美元的税后非现金费用（用于与 NATRECOR（奈西立肽）相关的无形资产减值），以及与某些国际子公司重组相关的2.67亿美元的税收收益。
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人们利用生物重组技术,成功地体外合成了BNP的人工合成品奈西利肽(Natrecor), 并得到了肯定的临床疗效。但是,由于BNP在半衰期短,并且易被循环中的酶降解,限制了其对心力衰竭的临床运用。
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nesiritide natrecor 内西利他
That drug - Natrecor - looked to be a blockbuster, but many doctors avoid it because of worries that it might raise the risk of death.
但许多医生因为担心该药物可能增加患者死亡风险而避而不用。
The bad news came from a test of Natrecor, a drug that had meteoric sales after its approval in 2001 because it was the only medicine that seemed to help shortness of breath.
坏消息则来自于对奈西立肽做的测验。这种药自2001年得到认可后，销量惊人，因为当时它被认为是唯一可能治疗呼吸急促的药。
One out of every six people hospitalized with heart failure were given Natrecor until it came under a cloud in 2005 when studies suggested it raised the risk of death and kidney problems.
当时，每六个因心衰住院的患者中有一个会被要求服用奈西立肽。直到2005年，多项研究证实，奈西立肽会增加死亡和肾脏问题的风险。到这时，它才失去了市场。
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