Results: in the naloxone-precipitated tests, after injecting sinomenine for 10 days continuously, the mice and rats didn't show any withdrawal symptom and the loss of body weight.
结果：在催促戒断试验中，受试的大、小鼠连续注射青藤碱10天后经纳洛酮催促，均未出现戒断症状及体重下降现象。
Conclusion: Both spinal and supraspinal neuronal Phosphoinositide 3-kinase (PI3K) pathway played important role in morphine dependent and naloxone-precipitated withdrawal response in mice.
结论：脊髓和脊髓上中枢神经元pi - 3 K信号通路均参与吗啡依赖的形成及戒断反应的表达。
In addition, the withdrawal symptoms precipitated by naloxone in morphine dependent rats were blocked by methoctramine(ip) or pirenzepine (it) at single dose injection in a dose dependent manner.
美索四氨或哌拉唑嗪以剂量依赖方式抑制吗啡依赖大鼠纳洛酮激发的戒断症状。
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