Objective to investigate the influence of fluorosis on nicotinic acetylcholine receptors (nAChRs) in protein and gene levels in SH-SY5Y cells and the mechanism of the receptor modification.

目的观察氟中毒对神经细胞中尼古丁受体亚单位蛋白和基因表达水平的影响及氟中毒引起尼古丁受体功能改变的发生机制。

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Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central nervous system, and they participate in complex neuronal signal transduction and regulation in the brain.

神经元烟碱受体广泛地分布于中枢神经系统并参与脑内信号传导系统的调节过程。

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According to the study, the nicotine vaccine led to a 12.5% reduction in nicotine binding to nAChRs, which was linked to a 23.6% decrease in the amount of nicotine available to enter the brain after vaccination.

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