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Even when a tumor is all but eliminated by Taxol, a few cells with mutated microtubules that are invulnerable to the drug can remain, growing into more deadly tumors.
FORBES: Taxol's Next Stand
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Eventually, huge numbers of these mutated proteins build up, form insoluble masses within cells, which kill them.
BBC: vCJD and BSE - the link
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However, when it is mutated it is unable to do this, leaving cells at risk of becoming potentially cancerous.
BBC: How gene causes breast cancer