They also work on methods for creating mutant cell lines that have lesions in signal transduction pathways, and appropriate ways to uncover the genetic basis of those lesions.

他们同时也致力于创建在信号转导途径存在缺陷的突变细胞株，并探索相关方法去揭示这些缺陷的遗传机理。

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They believe a single type of cell may be cancer's main growth engine:mutant stem cells that, though barely present, spawn other cells that then spark growth.

FORBES: Cancer Killer

To thrive, they latch onto a healthy host cell and hijack its reproductive machinery, cranking out copies of themselves and spinning off mutant versions that resist any one drug.

FORBES: The Golden Age of Antiviral Drugs