Chronic renal failure presents multiple difficult problems in the absence of adequate medical treatment despite all efforts to date.

所有努力成果迄今，在缺乏医学治疗的情况下，慢性肾衰竭会引起多样困难的问题产生。

youdao

In fact, in spite of multiple serious and very public legal, medical, and personal problems over the years, both CBS and WB have remained, until now, unmitigated fans of Sheen and his show.

FORBES: Charlie Sheen And Public Company Disclosure

Two studies published in the Journal of the American Medical Association - on football in the UK and the US - have found a link between multiple concussions and neuropsychological problems.

BBC: 'Brain damage risk' from popular sports