Objective To solve the problem of non-inferiority test by adjusting central effect in multicenter trials.

目的解决校正中心效应的非劣性检验的问题。

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Phase III studies are multicenter trials on large patient groups designed to be the definitive assessment of a drug's effectiveness.

三期研究是为最终评估药物有效性而在大批病人中进行的试验。

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The ACCP guidelines do not support the use of aspirin for prophylaxis following TJA, because this drug has not been extensively evaluated in multicenter randomized trials.

ACCP指南不支持在TJA术后使用阿斯匹林预防血栓性疾病，因为该药还没有在多中心随机试验中得到进一步评估。

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Clinical results from any specialized cancer center are typically very difficult to reproduce in broader multicenter trials, in part because there may be differences, whether measured or unmeasured, between those presenting at renowned centers of excellence and those who remain close to home.

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