In the most sad, cannot lose faith; In the happiest time, cannot forget the setbacks.

在最悲伤的时候，不能失去信念；在最幸福的时候，不能忘记挫折。

youdao

Face, not necessarily the most sad. Alone, not necessarily not happy. Get, can not long. Lost, not necessarily have no longer.

面对，不一定最难过。孤独，不一定不快乐。得到，不一定能长久。失去，不一定不再拥有。

youdao

You can love many people, but only one person makes you laugh the most brilliant, most sad cry.

可以爱很多人，但只有一个人会让你笑得最灿烂，哭得最伤心。

youdao

"Then I can only say I am most sad to hear it,"

VOA: special.2009.06.25

One of the most famous of these sad songs is "Your Cheatin' Heart."

VOA: special.2009.11.22

What is most sad about critics such as Dr. Salzberg is their apparent decision that safety and effectiveness take a back seat to their opinion of current science protocols.

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And few bands in recent years have experienced as much source material when it comes to personal turmoil: The tragic death of a former band member and a current member's hospitalization after kidney failure helped inspire the band's 2007 album Asleep at Heaven's Gate, one of the decade's most profoundly sad and moving rock records.

NPR: Rogue Wave: To Sunnier Days Ahead

The sad truth is most investors suffer from "loss aversion"--they don't sell loser stocks when they should.

FORBES: Magazine Article