The most difficult thing in a fast game of basketball is to change course midstream.

在一场快节奏的篮球比赛中，最难之事莫过于中途变线了。

《柯林斯英汉双解大词典》

It is getting much easier to travel nowadays, but increasingly harder to get away from people, and that is perhaps the most difficult thing for holiday makers.

现在旅行变得越来越容易了，但是要远离人群却越来越难，这也许是度假者最困难的事情。

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The most difficult thing for university student Ted Rogers is opening his classroom door.

对于大学生特德·罗杰斯来说，最困难的事情就是去打开教室的门。

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"The more banal he is, the more terrifying he is. There is no doubt and I'll say without question that it was the most difficult thing I've ever done as an actor."

VOA: standard.2010.01.08

Most of us find that rather difficult thing to believe that the person could be constantly changing in this way without having any way at all to tell.

大多数人很难相信,人可以不断地,变化，而且是以这种,无法揣测的方式变化。

耶鲁公开课 - 死亡课程节选

"I think the most difficult thing will be to be separated from the people that I am used to, and leaving behind some of the habits - all our activity will be directed towards a certain goal."

VOA: standard.2010.06.02

"Probably the most difficult thing is speaking English all day, " he says, massaging his jaw.

WSJ: Snapshot of a Curator | Quentin Bajac | Cultural Conversation by Richard B. Woodward

The most difficult thing in my journey is the way that people have reacted to my making money.

FORBES: Bethenny Frankel And The One Question She's Never Been Asked: 'Are You Happy?'

But no I think it is probably the most difficult thing we've done and also the most important.

BBC: NEWS | Programmes | Breakfast with Frost | Economy is key battleground