Among all of these protocols, combining blockade of co-stimulatory signals with donor specific bone marrow transplantation to establish allogeneic mixed chimerism is the one that has the best prospect to be used in the clinic.
其中,阻断T细胞活化的共刺激信号联合供者特异性骨髓移植建立异基因混合嵌合体,是目前所知最具临床应用前景的一种耐受诱导策略。
参考来源 - 腺病毒介导CTLA4Ig基因转染联合供者特异性细胞输注诱导小鼠皮肤移植耐受的研究·2,447,543篇论文数据,部分数据来源于NoteExpress
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