Among all of these protocols, combining blockade of co-stimulatory signals with donor specific bone marrow transplantation to establish allogeneic mixed chimerism is the one that has the best prospect to be used in the clinic.
其中，阻断T细胞活化的共刺激信号联合供者特异性骨髓移植建立异基因混合嵌合体，是目前所知最具临床应用前景的一种耐受诱导策略。
参考来源 - 腺病毒介导CTLA4Ig基因转染联合供者特异性细胞输注诱导小鼠皮肤移植耐受的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
Objective To assessed the ability of FK506 and antilymphocyte serum(ALS) to induce mixed chimerism and tolerance for knee composite tissue allograft in rabbits without chronic immunosuppression.
目的探讨短期使用FK5 0 6和抗淋巴细胞血清（ALS）诱导兔同种异体膝关节移植嵌合耐受的作用。
Some experimental protocols were introduced including mixed chimerism of allogeneic bone marrow, blockade of co-stimulation signal and transgene technology for transplantation tolerance induction.
介绍一些具体方案，包括建立异基因骨髓嵌合体、阻断T细胞活化第二信号和转基因技术诱导移植免疫耐受。
Mixed hematopoietic chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different individuals coexist.
造血干细胞混合嵌合体是指两个不同基因型个体的骨髓造血干细胞共存的一种状态。
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