Objective To study the effects of high glucose on activity of mitogen activated protein kinase (MAPK) in cultured human mesangial cells and to explain the mechanism of diabetic nephropathy.

目的：研究高糖对人肾小球系膜细胞丝裂原蛋白激酶（MAPK）活性的影响，探讨其在糖尿病肾病发病中的作用。

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Mitogen activated protein (MAP) kinase, also known as extracellular signal regulated kinase, or ERK, functions in neuronal signal transduction and participates in diverse development processes.

丝裂原激活的蛋白激酶又称细胞外信号调节激酶，具有神经元信号传导功能，参与多种发育过程。

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Mutations in GNA11 induced spontaneously metastasizing tumors in a mouse model and activated the mitogen-activated protein kinase pathway.

在小鼠模型中，GNA11突变诱导了自发转移性肿瘤，激活了丝裂原活化蛋白激酶途径。

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AstraZeneca is in midstage trials with 180 melanoma patients for a drug that hits a related target called mitogen-activated protein kinase kinase.

FORBES: Magazine Article

AstraZeneca (nyse: AZN - news - people ) is in midstage trials with 180 melanoma patients for a drug that hits a related target called mitogen-activated protein kinase kinase.

FORBES: Targeting Melanoma