The New Zealand-born centre will win his 10th cap after missing the autumn series through injury.

BBC: England pick prop Dan Cole & recall centre Riki Flutey

Tomas O'Leary, left out of the original squad, returns at scrum-half after missing the autumn series with injury.

BBC: Fergus McFadden to win first Ireland cap against Italy

It is a big blow for Moody, who was hoping to re-establish himself in the England side after missing the autumn internationals following an ankle operation.

BBC: Injured Moody out of Six Nations