One reason is that mathematics builds on itself, so that one missed step can lead to a lifetime of failure.

其中一个原因是由于数学是不断建立在自身基础上，因此人一旦错失其中的一步都可能导致终身数学方面的失败。

youdao

I missed out on some once-in-a-lifetime trips. My fiance went all over Europe in college and I am very jealous of her for it.

如果可以就去国外念书，我错过了许多次千载难逢的旅行机会，我未婚妻就曾在大学时游遍欧洲，对此我非常的妒忌。

youdao

Study abroad if you can. I missed out on some once-in-a-lifetime trips. My fiance went all over Europe in college and I am very jealous of her for it.

如果可以就去国外念书，我错过了许多次千载难逢的旅行机会，我未婚妻就曾在大学时游遍欧洲，对此我非常的妒忌。

youdao

Samson Oni just missed out on a lifetime best 2.31m to finish third ahead of GB team-mate Martyn Bernard.

BBC: Banishing the Beijing demons

Imagine how many once-in-a-lifetime moments he has missed.

CNN: Men don't have it all either

Most excuses are less creative: doctor's order, child-care issues, work that can't be missed, a planned once-in-a-lifetime vacation.

WSJ: Psst! You Want to Duck Jury Duty?