According to the National Institutes of Healt h, most fish oil studies have involved the use of 300 to 3, 000 mg of the essential fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).

FORBES: The Fish Oil Debate: Great Brain Medicine, or Just an Expensive Placebo?

But in an Arena study published online this week in the journal Circulation: Cardiovascular Imaging, evaluation of over 5, 200 patients in phase 3 trials of 52 weeks of lorcaserin (10 mg, twice daily) or placebo showed only a slight difference in heart valve problems: 2.04% for placebo and 2.37% for lorcaserin.

FORBES: Why Does Arena's Obesity Drug Have Abuse Potential?

In one study, the average weight loss for a group taking a higher dose (32 mg) of naltrexone plus bupropion for about a year was 6.1% while for a lower dose (16 mg) it was 5%. (People taking a placebo had an average weight loss of 1.3%.) However, only half the participants who started the trial actually finished it.

CNN: Combo of old drugs offers new hope in obesity fight