Conclusion Abnormal methylation of TPEF gene is a frequent event and may become a promising diagnostic marker for early detecting colorectal carcinoma.

结论大肠癌患者TPEF基因甲基化为一频繁发生事件，可望成为大肠癌早期诊断的一个标志物。

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Many studies showed that DNA methylation is specific marker of NSCLC in its diagnosis, staging, treatment and prognosis.

研究显示，DNA甲基化是非小细胞肺癌（NSCLC）诊断、分期及治疗预后特异性较强的标识物。

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Objective:To explore whether detecting minimal residual disease of leukemia with hyper-methylation of the calcitonin gene as molecular genetic marker of leukemic clone to predict the prognosis.

目的：探讨以降钙素基因高度甲基化为白血病克隆的分子基因标志，检测白血病微量残留病，并预测预后的可能性。

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