The results indicate that MDM2 gene may play an important role in the pathogenesis and the process of metastasis of NPC.
提示MDM2基因在NPC中的主要活化方式是高表达而不是扩增，MDM2基因的高表达可能在NPC的发生和转移过程中起着重要作用。
The effect of MDM2 on the transcriptional activity of er was detected by the reporter gene containing estrogen responsive elements luciferase (ERE-LUC).
以含雌激素反应元件的荧光素酶(ERE - LUC)为报告基因，通过检测荧光素酶活性来确定MDM2是否对ER有转录调节因子的作用。
All 5 cases exhibited at least focal classic histologic findings. All harbored DDIT3 gene rearrangements, and none harbored MDM2 amplifications according to fluorescence in situ hybridization.
这5例至少局灶存在经典的组织学形态，荧光原位杂交检测DDIT3基因均出现重排，无mdm2扩增。
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