"This is something that's come up every nine months to a year, " says Matthew Osborne, an analyst at Lazard Capital Markets.

FORBES: Dark Cloud Over Amylin

Matthew Osborne at Lazard Capital Markets raised his price target on Celgene slightly, arguing the boost given to Celgene's international presence and pipeline could outweigh the dilutive aspects of the deal.

FORBES: Celgene's Smart Buy

Conservative MP Matthew Hancock, a former economic adviser to Mr Osborne, said the "controversial decisions" taken in the Budget should be seen in the context of the Chancellor's wider strategy.

BBC: Budget debate