The synthetic technique of pharmacopoeia grade DL-malic acid through orthogonal test was studied.
采用正交设计试验研究了药典级DL -苹果酸的合成工艺。
Objective: To optimize the preparation of miconazole nitrate malic acid-chitosan microsphere with uniform test design, the stability and release of microsphere were studied.
目的：以均匀设计法筛选优化硝酸咪康唑苹果酸化壳聚糖微球的制备工艺，提供可控性及预测性，并对微球稳定性和药物释放规律进行研究。
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