Lymphocytes are a type of white blood cell involved in immune function and are categorized as either B-cells or T-cells. This newly discovered element, CD19-L, is expressed on the surface of T-lymphocytes and allows them to selectively bind to the CD19 receptor on the surface of B-lineage leukemia cells, and most importantly on leukemic stem cells responsible for the survival and expansion of the leukemia cell population. Once the CD19-L binds to leukemia cells, cell death occurs. Although CD19 is abundantly expressed on leukemia cells from B-lineage ALL patients, it is absent on red cells, T-cells, and normal bone marrow stem cells, making it specific, and therefore, a good therapeutic target.
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So, making gene therapy specific is a key problem in making it work.
所以基因治疗中,特异性对能否成功就至关重要了
First of all, it suggests of course that he was giving language to something, making a specific image out of something, that didn't quite have that specific content in his experience as a child.
第一,这的确可以反映出,他是在描述东西,运用某种东西来描述一个形象,在他作为孩子的经历中,那东西没有特殊的意义。
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