It won't make a scrap of difference.

这不会有丝毫的差别。

《牛津词典》

What difference will it make if he knows or not?

他知不知道有什么关系吗？

《牛津词典》

Tom, it don't make no difference.

汤姆，这没什么差别。

youdao

A few degrees can make a big difference when it comes to food storage.

VOA: special.2009.02.09

What difference would it make had Frost, as he could have, I suppose, reversed the order of lines 13 and 14?

如果把13行与14行颠倒之后，会发生什么呢？

耶鲁公开课 - 现代诗歌课程节选

What difference would it make between those two things, between knowing that heart and merely feeling it?

这两者有什么不同呢,懂得与感受这两者，到底有没有不同呢？

耶鲁公开课 - 现代诗歌课程节选

Does it really make any difference whether it is a loan or not ?

FORBES: Move up http://i.forbesimg.com t Move down

And I know that if hard work could make the difference for me, then it can make a difference for all of you.

WHITEHOUSE: The President��s Back to School Speech

While a bachelor degree may not guarantee getting that first job sooner than later, it can certainly make the difference when it comes to advancing to managerial positions or moving across occupations.

FORBES: Why Is It Difficult To Get That First Job?