He needed to make a complete break with the past.

他得与过去彻底告别。

《牛津词典》

She wanted to make a clean break with the past.

她想与过去完全断绝。

《牛津词典》

It's make-or-break time for the company.

这是公司盛衰的关键时刻。

《牛津词典》

They make proteins including oxygen-carrying blood substances, antibodies to protect against disease, and substances that break down sugar.

VOA: special.2009.12.08

And so, the philosopher, who has sort of trained himself to separate his mind from his body, to disregard his bodily cravings and desires-- the philosopher will welcome death because at that point he'll truly, finally, make the final break from the body.

所以,那些,已经为灵魂脱离肉体,以及忽视自己的肉体欲望,做好准备的哲学家,将会欢迎死亡的到来,那时他会真正地,最终地,从自己的肉体中解脱出来

耶鲁公开课 - 死亡课程节选

You can also add other assumptions to be tested and drag the riskiest premises make-or-break propositions that, if they were wrong, would make your business fundamentally unworkable to the top of the list.

FORBES: LeanLaunchLab: Online Tools For Focused, Nimble Startups

Confirmation that Naved would join Yorkshire came after a make-or-break fitness test with physio Scott McAllister.

BBC: Naved given Yorkshire clearance

Sanchez is headed into his fifth season with the Jets, likely a make-or-break year for him.

WSJ: Jets' Sanchez hopeful, learning new offense