I don't know if it is a major risk.

我不知道这是不是一个大的冒险。

youdao

Tobacco use is a major risk factor for cancer.

烟草使用是癌症的一大高危因素。

youdao

Voute says obesity is another major risk factor.

伍特谈到，肥胖是另一个主要危险因子。

youdao

One major risk factor is a diet filled with fat and salt.

VOA: standard.2010.04.22

That's because the most important risk that individuals face is the risk of major losses of income.

因为个人所面临的最大风险,就是收入的大量流失。

耶鲁公开课 - 金融市场课程节选

"How do you make sure you are designing a system where you are going to constrain risk taking, you can prevent crises from spreading,and -- if a major institution managed itself to the edge of the abyss -- that we are able to put them out of their misery."

VOA: special.2010.04.16

Other major risk factors for periodontal disease include genito-urinary infections, smoking and excessive alcohol drinking.

BBC: Gum disease 'risks unborn babies'

But it is known that obesity is a major risk factor in heart disease, diabetes and some cancers.

FORBES: A Cautionary Tale: 575-Pound Spokesman for 'Heart Attack Grill' Dies at 29

Because LDL cholesterol is a major risk factor for heart disease, it's the main focus of cholesterol-lowering treatment.

CNN: Cholesterol levels: What numbers should you aim for?