This could make your superiors hesitate to trust you with major responsibilities.

这可能会使你的上司犹豫着不愿把重大职责托付给你。

《柯林斯英汉双解大词典》

What are your major responsibilities?

你的主要职责是什么？

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What are the job's major responsibilities?

这份工作的主要职责是什么？

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Foreign Minister Zebari insisted that he doesn't think that the recent surge of violence will disrupt the timetable for U.S.troops to withdraw from major Iraqi cities in June, or for assuming security responsibilities across the country.

VOA: standard.2009.04.25

That these kids (at least in this aging man's eyes) can carry out major responsibilities in such a dangerous environment is extraordinary.

FORBES: Fact And Comment

Below are the five major responsibilities of a fiduciary.

FORBES: What Every Client Needs To Know, But Didn't Know To Ask

The last time we devoted a lesser proportion of our resources to defense, we were well protected by the oceans, in the midst of a depression, and without major international responsibilities, and even then it was a dereliction of duty.

CENTERFORSECURITYPOLICY: Center For Security Policy