Interestingly, there's some speculation that humans started having a major impact on Earth much earlier, about 8000 years ago.
有趣的是，有一些推测认为，人类对地球产生重大影响的时间要早得多，大约应该在8000年前。
Most important, scientists are beginning to realize that the climatic changes have had a major impact on the evolution of the human species.
最重要的是，科学家们开始意识到，气候变化对人类物种的进化产生了重大影响。
Even a slowdown at the border would have a major impact on both countries.
VOA: standard.2009.04.30
Community leaders say donating basic goods like milk powder and aspirin, which can be scarce in Cuba, has a major impact for Cuban families struggling to survive under Communist rule.
VOA: standard.2009.10.23
Despite concerns about the impact of reforms on Wall Street, the three major U.S.indexes closed higher on Friday.
VOA: standard.2010.05.21
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