... 分布容积、清除率、血药峰值浓度、血浆半衰期、药物剂 量的设计和优化 靶浓度(target concentration) 维持量(maintenance dose) 负荷量（loading dose）:首次剂量加大，然后再给予维 持剂量，使稳态治疗浓度提前产生。
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Methods:The open and self-controlled study was conducted in 47 patients with diagonized epilepsy. In addition to their original regimen maintained,they were also treated with topiramate in an initial dose of 50 mg*d-1,then increased to 100 mg*d-1 in 2 divided dose after 2 weeks,and with a maintenance dose of 200～400 mg*d-1 thereafter.
方法：进行开放性自身对照临床试验，对47例经临床和EEG确诊的癫痫患者在原有抗癫痫药物治疗不变的基础上，添加妥泰治疗，初始剂量为50mg*d-1，2周后为100mg*d-1，分2次服用，维持剂量200～400mg*d-1。
参考来源 - 添加托吡酯治疗癫痫的临床研究 Study of the efficacy of topiramate added to regimen for treatment of epilepsy·2,447,543篇论文数据，部分数据来源于NoteExpress
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