Methods: to read the related literatures then to review and comment the B lymphocyte development and BCR gene rearrangement.

方法：通过相关文献的阅读，综合评述B细胞发育与BCR基因重排。

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Conclusion: B lymphocyte development and BCR gene rearrangement is an ordered sequence. However, a lot of events in this procedure are unclear.

结论：B细胞发育及BCR基因重排是一个密切相关的十分有序的过程，但仍有许多问题未弄清楚。

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The changes of peripheral T lymphocyte subsets and decrease of NK cells, which lead to proliferation of B cells, may play an important role in the development of SLE.

淋巴细胞亚群的改变和NK细胞活性降低，导致B细胞功能亢进，产生多种自身抗体，在SLE的发病机理中起重要作用。

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