abstract:Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene.
Hefound neurons lackingLRP1 had even less ability to absorbcholesterol, and that they lost synapticcontactwithotherneurons, impairing theirability to retain memory.