The effect of a disease - or a condition like obesity - can be tallied by a measure called quality-adjusted life years lost.

VOA: standard.2010.08.10

Often people in his state of mind will refuse treatment because they have lost all insight into their condition.

CNN: How can I help someone I fear is abusing Adderall?

The condition worsened until four years ago when Mr Kennish fell over and lost the feeling in one of his legs.

BBC: Darren Kennish from the Isle of Man

Its feet had been lost at some point in the intervening five centuries, but the rest of the bones were in good condition, which archaeologists and historians say was incredibly lucky, given how close later building work came to them -- brick foundations ran alongside part of the trench, within inches of the body.

CNN: February 5, 2013 -- Updated 1411 GMT (2211 HKT)